Can I take Magnesium and Dapagliflozin together?
Drug interaction guide
Originally published 12 May 2026
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Taking magnesium supplements alongside dapagliflozin may increase the risk of dehydration and low blood pressure. Both substances can have a mild diuretic effect (making you pass more urine). Additionally, magnesium may slightly interfere with how much dapagliflozin your body absorbs if taken at the exact same time.
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Why this happens
Dapagliflozin works by removing glucose and water through the kidneys. Magnesium can also act as an osmotic laxative or diuretic. Together, they may increase fluid loss. There is also a potential for magnesium to bind with certain medications in the digestive tract, potentially reducing their absorption.
What you should do
Back to contentsIt is generally safe to take both, but you should stay well-hydrated by drinking plenty of water. To ensure the best absorption of your medication, try to space them out by at least 2 hours. Monitor yourself for signs of dehydration or dizziness when standing up. If you feel very lightheaded, speak to your doctor.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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