Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer
This study is investigating the long-term safety of a type of breast surgery called nipple-sparing mastectomy. This operation allows women at high genetic risk of breast cancer to have a mastectomy (breast removal) to reduce their risk, while also keeping their nipple and the darker skin around it (areola). Many women prefer this option for their body image and well-being, but there isn't much long-term information yet on how safe it is, especially for preventing future cancers when compared to other types of mastectomy. This research aims to provide more clear answers by following women with specific genetic changes for a longer time, helping doctors give the best advice.
एक नजर में
यह अध्ययन किस बारे में है?
Imagine you have a strong family history of breast cancer, or genetic test results show you have a higher chance of developing it. One option some women consider is surgery to remove their breasts to significantly lower this risk. This is called a risk-reducing mastectomy.
There are different ways to do this surgery. Historically, the nipple and the skin around it were removed. However, a newer technique called 'nipple-sparing mastectomy' allows surgeons to remove the breast tissue, but keep the nipple and areola intact. Many women find that keeping these parts of their breast helps them feel much better about their body and reduces feelings of disfigurement after surgery.
Even though nipple-sparing mastectomy can have these important benefits for a woman's well-being, doctors still need more long-term information to be absolutely sure it's as safe as other types of mastectomy for cancer prevention, especially for women with certain genetic risks. This study aims to gather that important long-term safety data. By following women for a longer time, researchers hope to confirm whether this type of surgery is just as effective at preventing breast cancer in those at high genetic risk.
मुख्य निष्कर्ष
- The study explores the long-term safety of nipple-sparing mastectomy.
- It's for women with specific genetic risks for breast cancer.
- The goal is to provide clearer evidence on this surgery for cancer prevention.
- Many women prefer this surgery for body image.
- More long-term data is needed for medical guidelines.
कौन पात्र हो सकता है?
This study is looking for women who were assigned female at birth and are 18 years old or older. You would need to have had a genetic test that confirmed you carry specific changes in certain genes known to increase the risk of breast cancer. These genes include BRCA1, BRCA2, PALB2, TP53, CDH1, or PTEN.
You wouldn't be able to join if you have already had breast cancer, or if you had ovarian cancer before your genetic testing. Also, if you've already had both breasts removed before your genetic test, you wouldn't be suitable for this study. Finally, if your genetic test showed a 'variant of uncertain significance' – meaning genetic changes whose role isn't yet fully understood – as your only genetic finding, this study wouldn't be right for you.
क्या यह अध्ययन आपके लिए उपयुक्त हो सकता है?
यह देखने के लिए इन त्वरित प्रश्नों का उत्तर दें कि क्या आप पात्र हो सकते हैं। यह केवल एक मार्गदर्शिका है — अंतिम निर्णय शोध टीम द्वारा लिया जाता है।.
- I am a woman and was assigned female at birth.
- मैं 18 वर्ष या उससे अधिक उम्र का हूँ।.
- I have had a genetic test that confirmed a specific genetic change (like BRCA1 or BRCA2) that increases my breast cancer risk.
- I have never had breast cancer before my genetic test.
- I have never had ovarian cancer before my genetic test.
- I have not had both breasts removed before my genetic test.
भागीदारी में क्या शामिल है?
The description does not provide details on what participation would involve in terms of visits, assessments, medication, or specific follow-up schedules. It mentions a focus on longer follow-up to confirm previous findings. To get a clear understanding of what joining this study would mean for you, you would need to speak directly with the research team.
संभावित जोखिम और लाभ
Locations (16)
- येल विश्वविद्यालयसत्यापित पोस्टकोडन्यू हेवन, संयुक्त राज्य अमेरिका· भर्ती
- Brigham and Women's Hospital - Dana-Farber Brigham Cancer Centerसत्यापित पोस्टकोडबोस्टन, संयुक्त राज्य अमेरिका· अभी भर्ती नहीं हो रही है
- Memorial Sloan Kettering Cancer Center (MSKCC)सत्यापित पोस्टकोडन्यूयॉर्क, संयुक्त राज्य अमेरिका· अभी भर्ती नहीं हो रही है
- University of Rochester, Wilmot Cancer Instituteसत्यापित पोस्टकोडरोचेस्टर, संयुक्त राज्य अमेरिका· अभी भर्ती नहीं हो रही है
- पेंसिल्वेनिया विश्वविद्यालयसत्यापित पोस्टकोडफिलाडेल्फिया, संयुक्त राज्य अमेरिका· भर्ती
- University of Melbourne, Peter MacCallum Cancer Centerसत्यापित पोस्टकोडमेलबर्न, ऑस्ट्रेलिया· अभी भर्ती नहीं हो रही है
- Ziekenhuis Aan de Stroomसत्यापित पोस्टकोडएंटवर्प, बेल्जियम· सक्रिय लेकिन भर्ती नहीं
- यूनिवर्सिटी ऑफ़ कैलगरीसत्यापित पोस्टकोडकैलगरी, कनाडा· भर्ती
- हैमिल्टन स्वास्थ्य विज्ञानसत्यापित पोस्टकोडहैमिल्टन, कनाडा· भर्ती
- Women's College Hospital, University of Torontoसत्यापित पोस्टकोडटोरंटो, कनाडा· अभी भर्ती नहीं हो रही है
- यहूदी जनरल अस्पतालसत्यापित पोस्टकोडमॉन्ट्रियल, कनाडा· भर्ती
- CHU de Quebec Université lavalसत्यापित पोस्टकोडक्यूबेक, कनाडा· भर्ती
सामान्य प्रश्न
What is a 'nipple-sparing mastectomy'?
It's a type of surgery where breast tissue is removed to reduce cancer risk, but the nipple and the darker skin around it (areola) are kept.
यह अध्ययन महत्वपूर्ण क्यों है?
It aims to confirm if nipple-sparing mastectomy is a safe long-term option for preventing breast cancer in women with certain genetic risks, especially since many prefer this surgery for their well-being.
Who can take part in this research?
Women aged 18 or over, who have specific genetic changes (like in BRCA1/2 genes) that increase their breast cancer risk, and who haven't had breast or ovarian cancer before their genetic testing.
What genes are they looking at?
The study is looking at women with changes in genes like BRCA1, BRCA2, PALB2, TP53, CDH1, or PTEN.
क्या मुझे इस अध्ययन में नया उपचार मिलेगा?
The study focuses on observing outcomes over time for women who have already had or are considering a nipple-sparing mastectomy, rather than providing a new treatment.
और अधिक जानने के लिए कैसे पता करें
Stephanie Wong, MD
किसी अध्ययन में भाग लेने का निर्णय लेने से पहले हमेशा अपने जीपी या विशेषज्ञ से बात करें।.
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