killin, p53 regulated DNA replication inhibitor
Last updated 2 Feb 2021
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
The KLLN gene provides instructions for making a protein called killin. The activity of the KLLN gene is controlled by a protein called p53 (which is produced from the TP53 gene). Little is known about the function of killin, although it is thought to trigger cells to self-destruct (undergo apoptosis) when they are damaged or no longer needed. In this way, killin helps to prevent abnormal cells from growing and dividing unchecked to form tumours. Through its role in regulating cell division, killin helps maintain the stability of a cell's genetic information. Based on these roles, killin is thought to be a tumour suppressor.
Normal function
The KLLN gene provides instructions for making a protein called killin. The activity of the KLLN gene is controlled by a protein called p53 (which is produced from the TP53 gene). Little is known about the function of killin, although it is thought to trigger cells to self-destruct (undergo apoptosis) when they are damaged or no longer needed. In this way, killin helps to prevent abnormal cells from growing and dividing unchecked to form tumours. Through its role in regulating cell division, killin helps maintain the stability of a cell's genetic information. Based on these roles, killin is thought to be a tumour suppressor.
Conditions referring to this gene or chromosome
Other names
KILIN_HUMAN
KILLIN
killin
killin, p53-regulated DNA replication inhibitor
Related patient information and medicines
Patient information leaflet
Chronic myeloid leukaemia
Chronic myeloid leukaemia (CML) is sometimes called chronic myelogenous leukaemia, chronic granulocytic leukaemia, or chronic myelocytic leukaemia. What is chronic myeloid leukaemia. Chronic myeloid leukaemia (CML) is sometimes called chronic myelogenous leukaemia, chronic granulocytic leukaemia, or chronic myelocytic leukaemia. CML develops due.
Patient information leaflet
Kidney cancer
The mos... If kidney cancer is diagnosed at an early stage, there is a good chance of a cure. A description of what kidneys are and how they work is at the bottom of this article. This is sometimes called renal adenocarcinoma or renal cell carcinoma or hypernephroma. Renal cell cancer This type of cancer develops from a cell in a kidney tubule,.
Patient information leaflet
Parkinson's disease
The main symptoms of Parkinson's disease are usually stiffness, shaking (tremor), and slowness of movement. Parkinson's disease symptoms The brain cells and nerves affected in Parkinson's disease (PD) normally help to produce smooth, co-ordinated movements of muscles. When this system goes wrong, movement disorders (motor symptoms) occur. Three.
Patient information leaflet
Genetic testing
Genetic testing is a type of medical test that identifies changes in chromosomes, genes or proteins. Genetic tests examine a person's DNA in a variety of ways to assess a person's genetic health. Chromosomes are made from DNA (deoxyribonucleic acid). Genes are short sections of DNA and each chromosome contains hundreds to thousands of genes. The.
Patient information leaflet
Medical negligence
There is a separate Health Service Ombudsman for England, Scotland, Wales and Northern Ireland. (In Northern Ireland, pharmacists are regulated by the Pharmaceutical Society of Northern Ireland). The Health and Care Professions Council (HCPC), for art therapists, biomedical scientists, chiropodists and podiatrists, clinical scientists, dieticians,.
Patient information leaflet
Diabetic kidney disease
Also, it aims to reduce the risk of developing cardiovascular diseases such as heart attack and stroke which are much more common than average in people with this disease. To find out more about the kidneys and urine, see the leaflet called What do kidneys do. Diabetic kidney disease is one of the causes of chronic kidney disease , a long-term.
Further reading and references
- killin, p53 regulated DNA replication inhibitor; MedlinePlus, National Library of Medicine.
- Bennett KL, Mester J, Eng C. Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome. JAMA. 2010 Dec 22;304(24):2724-31. doi: 10.1001/jama.2010.1877.
- Jelovac D, Park BH. PTEN promoter silencing and Cowden syndrome: the role of epigenetic regulation of KILLIN. JAMA. 2010 Dec 22;304(24):2744-5. doi: 10.1001/jama.2010.1863. No abstract available.
- Nizialek EA, Sankunny M, Niazi F, Eng C. Cancer-predisposition gene KLLN maintains pericentric H3K9 trimethylation protecting genomic stability. Nucleic Acids Res. 2016 May 5;44(8):3586-94. doi: 10.1093/nar/gkv1481. Epub 2015 Dec 15.
- Sankunny M, Eng C. Identification of nuclear export signal in KLLN suggests potential role in proteasomal degradation in cancer cells. Oncotarget. 2020 Dec 15;11(50):4625-4636. doi: 10.18632/oncotarget.27833. eCollection 2020 Dec 15.
- Sankunny M, Eng C. KLLN-mediated DNA damage-induced apoptosis is associated with regulation of p53 phosphorylation and acetylation in breast cancer cells. Cell Death Discov. 2018 Sep 11;4:31. doi: 10.1038/s41420-018-0094-x. eCollection 2018.
Join the conversation
Share your thoughts or experiences with others in our patient communities.
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.