Core binding factor acute myeloid leukemia
अंतिम अद्यतन 8 Sept 2020
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Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and platelets (thrombocytes) that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.
विवरण
Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and platelets (thrombocytes) that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.
People with CBF-AML have a shortage of all types of mature blood cells: a shortage of white blood cells (leukopenia) leads to increased susceptibility to infections, a low number of red blood cells (anaemia) causes fatigue and weakness, and a reduction in the amount of platelets (thrombocytopenia) can result in easy bruising and abnormal bleeding. Other symptoms of CBF-AML may include fever and weight loss.
While acute myeloid leukemia is generally a disease of older adults, CBF-AML often begins in young adulthood and can occur in childhood. Compared to other forms of acute myeloid leukemia, CBF-AML has a relatively good prognosis: about 90 percent of individuals with CBF-AML recover from their disease following treatment, compared with 25 to 40 percent of those with other forms of acute myeloid leukemia. However, the disease recurs in approximately half of them after successful treatment of the initial occurrence.
Inheritance patterns
The source lists the following possible inheritance patterns: Not inherited. More than one pattern can apply in different cases.
Related genes
Other names
CBF acute myeloid leukemia
CBF-AML
Core-binding factor AML
Related patient information and medicines
Patient information leaflet
तीव्र माइलॉयड ल्यूकेमिया
तीव्र माइलॉयड ल्यूकेमिया है where the bone marrow makes large numbers of abnormal immature white blood cells which are derived from a myeloid stem cell. What is acute myeloid leukaemia. Acute myeloid leukaemia (AML) है a condition where the bone marrow makes large numbers of abnormal immature white blood cells which are derived from a myeloid stem.
Patient information leaflet
ल्यूकेमिया
ल्यूकेमिया है a cancer of blood-forming cells. There are different types of leukaemia. If you develop leukaemia it is important to know what type it is. Before discussing the different types of leukaemia it may help to know some basics... The main types of leukaemia Acute lymphoblastic leukaemia (ALL). Chronic lymphocytic leukaemia (CLL). Acute.
Patient information leaflet
बचपन का ल्यूकेमिया
ल्यूकेमिया is a कैंसर of the cells which develop into blood cells. Most children with leukaemia will have acute lymphoblastic leukaemia. Some will have acute myeloid leukaemia. This leaflet gives a general overview of childhood leukaemias. Leukaemia is a cancer of cells in the bone marrow (the cells which develop into blood cells)... Acute myeloid.
Patient information leaflet
क्रोनिक माइलॉयड ल्यूकेमिया
क्रोनिक माइलॉयड ल्यूकेमिया (CML) is sometimes called chronic myelogenous leukaemia, chronic granulocytic leukaemia, or chronic myelocytic leukaemia. What is chronic myeloid leukaemia. Large numbers of these cells are made in the bone marrow and spill into the bloodstream. (In contrast, in acute myeloid leukaemia (AML) यह abnormal cells that are.
Patient information leaflet
बच्चों के कैंसर
There are many different types of chil... The following list includes the most common types of childhood cancer: Leukaemia Leukaemia is a cancer of the bone marrow and blood. It is the most common type of childhood cancer. There are two main types of childhood leukaemia - तीव्र lymphoblastic ल्यूकेमिया और acute myeloid leukaemia. Chronic myeloid.
Patient information leaflet
प्रतिरक्षा प्रणाली
This leaflet gives a brief overview of the प्रतिरक्षा प्रणाली and how it works. A person with a weak immune system might have difficulty fighting off infections. In autoimmune diseases the body is unable to tell what is its own and what is foreign, so it attacks itself. Some disorders of the immune system include: HIV and AIDS - when your immune system.
अधिक पठन और संदर्भ
- Core binding factor acute myeloid leukemia; MedlinePlus, National Library of Medicine.
- Goyama S, Mulloy JC. Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol. 2011 Aug;94(2):126-133. doi: 10.1007/s12185-011-0858-z. Epub 2011 May 3.
- Kuykendall A, Duployez N, Boissel N, Lancet JE, Welch JS. Acute Myeloid Leukemia: The Good, the Bad, and the Ugly. Am Soc Clin Oncol Educ Book. 2018 May 23;38:555-573. doi: 10.1200/EDBK_199519.
- Lam K, Zhang DE. RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis. Front Biosci (Landmark Ed). 2012 Jan 1;17(3):1120-39. doi: 10.2741/3977.
- Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol. 2011 Feb 10;29(5):475-86. doi: 10.1200/JCO.2010.30.2554. Epub 2011 Jan 10.
- Paschka P, Dohner K. Core-binding factor acute myeloid leukemia: can we improve on HiDAC consolidation? Hematology Am Soc Hematol Educ Program. 2013;2013:209-19. doi: 10.1182/asheducation-2013.1.209.
- Sangle NA, Perkins SL. Core-binding factor acute myeloid leukemia. Arch Pathol Lab Med. 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS.
- Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L, O'Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD, Demeter RT, Vickery TL, Hundal J, Cook LL, Swift GW, Reed JP, Alldredge PA, Wylie TN, Walker JR, Watson MA, Heath SE, Shannon WD, Varghese N, Nagarajan R, Payton JE, Baty JD, Kulkarni S, Klco JM, Tomasson MH, Westervelt P, Walter MJ, Graubert TA, DiPersio JF, Ding L, Mardis ER, Wilson RK. The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012 Jul 20;150(2):264-78. doi: 10.1016/j.cell.2012.06.023.
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