Genetic epilepsy with febrile seizures plus
अंतिम अद्यतन 18 अगस्त 2025
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Genetic epilepsy with febrile seizures plus (GEFS+) is a spectrum of seizure disorders of varying severity. GEFS+ is usually diagnosed in families whose members have a combination of febrile seizures, which are triggered by a high fever, and recurrent seizures (epilepsy) of other types, including seizures that are not related to fevers (afebrile seizures). The additional seizure types usually involve both sides of the brain (generalized seizures); however, seizures that involve only one side of the brain (partial seizures) occur in some affected individuals. The most common types of seizure in people with GEFS+ include myoclonic seizures, which cause involuntary muscle twitches; atonic seizures, which involve sudden episodes of weak muscle tone; and absence seizures, which cause loss of consciousness for short periods that appear as staring spells.
विवरण
Genetic epilepsy with febrile seizures plus (GEFS+) is a spectrum of seizure disorders of varying severity. GEFS+ is usually diagnosed in families whose members have a combination of febrile seizures, which are triggered by a high fever, and recurrent seizures (epilepsy) of other types, including seizures that are not related to fevers (afebrile seizures). The additional seizure types usually involve both sides of the brain (generalized seizures); however, seizures that involve only one side of the brain (partial seizures) occur in some affected individuals. The most common types of seizure in people with GEFS+ include myoclonic seizures, which cause involuntary muscle twitches; atonic seizures, which involve sudden episodes of weak muscle tone; and absence seizures, which cause loss of consciousness for short periods that appear as staring spells.
The most common and mildest feature of the GEFS+ spectrum is simple febrile seizures, which begin in infancy and usually stop by age 5. When the febrile seizures continue after age 5 or other types of seizure develop, the condition is called febrile seizures plus (FS+). Seizures in FS+ usually end in early adolescence.
A condition called Dravet syndrome (also known as severe myoclonic epilepsy of infancy or SMEI) is often considered part of the GEFS+ spectrum and is the most severe disorder in this group. Affected infants typically have prolonged seizures lasting several minutes (status epilepticus), which are triggered by fever. Other seizure types, including afebrile seizures, begin in early childhood. These types can include myoclonic or absence seizures. In Dravet syndrome, these seizures are difficult to control with medication, and they can worsen over time. A decline in brain function is also common in Dravet syndrome. Affected individuals usually develop normally in the first year of life, but then development stalls, and some affected children lose already-acquired skills (developmental regression). Many people with Dravet syndrome have difficulty coordinating movements (ataxia) and intellectual disability.
Some people with GEFS+ have seizure disorders of intermediate severity that may not fit into the classical diagnosis of simple febrile seizures, FS+, or Dravet syndrome.
Family members with GEFS+ may have different combinations of febrile seizures and epilepsy. For example, one affected family member may have only febrile seizures, while another also has myoclonic epilepsy. While GEFS+ is usually diagnosed in families, it can occur in individuals with no history of the condition in their family.
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal dominant. More than one pattern can apply in different cases.
Related genes
Other names
GEFS+
Generalized epilepsy with febrile seizures plus
Related patient information and medicines
Patient information leaflet
बुखार के दौरे
A febrile seizure is a convulsion that occurs in some children with a high temperature (fever). Having the febrile seizure does not cause the epilepsy but a child who is going to develop epil... नया studies suggest that children with febrile seizures हैं अधिक likely to have differences in genes relating को fever response as well as में several.
Patient information leaflet
दौरे के प्रकार
You can find out more from our leaflet called Febrile seizure (Febrile convulsion). They include: A genetic tendency to have seizures. This is probably the reason for दौरे in in most people who have epilepsy; they have संभावित inherited a combination of different gene variants that make their brain more vulnerable to having a seizure. Many.
Patient information leaflet
मिर्गी
We think that there is a close link between ge... It's thought that people with मिर्गी have a genetic tendency to have seizures, or a lower seizure threshold. This tendency can be विरासत में मिला from one या both parents, या it can develop for the first time as a new genetic change in the person with epilepsy. This genetic tendency is often due to.
Patient information leaflet
कठिनाइयाँ
How is a rigor different from a febrile convulsion या एक seizure. बुखार के दौरे हैं a type of seizure that can happen when a child, between the ages of 6 months and 6 years, has a high temperature (fever). देखें separate leaflet called Febrile Seizure (Febrile Convulsion) for more information. Seizures may also arise in people who have an.
Patient information leaflet
मिर्गी की दवा और दुष्प्रभाव
Medicines that हैं used to treat epilepsy work by stabilising the electrical activity of the brain. You need to take medication every day to... Counselling Some people with epilepsy become anxious or depressed about their condition. Genetic counselling may be appropriate if the type of epilepsy is thought to have an hereditary pattern. Standby.
Patient information leaflet
आनुवंशिक परीक्षण
आनुवंशिक परीक्षण is a type का medical test that identifies changes in chromosomes, genes or proteins. Genetic tests examine a person's DNA in a variety of ways to assess a person's genetic health. They are all designed to identify a particular gene that may cause a genetic disorder. We all have 46 chromosomes in our cells. One chromosome from each.
अधिक पठन और संदर्भ
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