ATP binding cassette subfamily C member 9
अंतिम अद्यतन 19 Nov 2025
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यह ABCC9 gene provides instructions for making the sulfonylurea receptor 2 (SUR2) protein. This protein forms one part (subunit) of a channel that transports charged atoms of potassium (potassium ions) across cell membranes. Each of these channels consists of eight subunits: four SUR2 proteins and four proteins produced from either the KCNJ8 या KCNJ11 gene. The SUR2 subunits regulate the activity of the channel, determining whether it is open or closed.
Normal function
यह ABCC9 gene provides instructions for making the sulfonylurea receptor 2 (SUR2) protein. This protein forms one part (subunit) of a channel that transports charged atoms of potassium (potassium ions) across cell membranes. Each of these channels consists of eight subunits: four SUR2 proteins and four proteins produced from either the KCNJ8 या KCNJ11 gene. The SUR2 subunits regulate the activity of the channel, determining whether it is open or closed.
Channels made with the SUR2 protein are known as ATP-sensitive potassium (K-ATP) channels. The channels open and close in response to the amount of ATP, the cell's main energy source, inside the cell. The resulting transport of potassium ions is part of a complex network of signals that relay chemical messages into and out of cells.
Although K-ATP channels are present in cells and tissues throughout the body, the highest levels of SUR2-containing channels are found in skeletal and heart (cardiac) muscle. These channels indirectly help regulate the concentration of calcium ions in cells. This regulation is essential for normal heart function. The function of these channels in other tissues is unclear.
Conditions referring to this gene or chromosome
Other names
ABC37
ABCC9_HUMAN
ATFB12
ATP-binding cassette sub-family C member 9
ATP-binding cassette sub-family C member 9 isoform SUR2A
ATP-binding cassette sub-family C member 9 isoform SUR2B
ATP-binding cassette transporter sub-family C member 9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
CANTU
CMD1O
sulfonylurea receptor 2
SUR2
Related patient information and medicines
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क्या मैं एटोरवास्टेटिन और फाइबर सप्लीमेंट्स को एक साथ ले सकता हूँ?
This means the statin may not work as well to lower your cholesterol. Why this happens Fibre supplements (like psyllium husk or methylcellulose) can bind to the atorvastatin in your stomach or intestines, preventing it से entering your bloodstream. What you should do You do not need to stop taking fibre, but you should separate the doses. Our.
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नेफ्रोटिक सिंड्रोम
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प्रतिरक्षा प्रणाली
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रक्त परीक्षण
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क्या मैं बिसोप्रोलोल और फाइबर सप्लीमेंट्स को एक साथ ले सकता हूँ?
Taking them without enough liquid can cause the supplement to swell a... Using other medicines Taking multiple medicines. Our दवाओं की परस्पर क्रिया जाँचकर्ता helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do.
Patient information leaflet
क्या मैं एटोरवास्टेटिन और बायोटिन को एक साथ ले सकता हूँ?
There is no known interaction between atorvastatin and biotin. It is generally considered safe to take these two together. Why this happens Atorvastatin is processed by specific liver enzymes (CYP3A4), while biotin (Vitamin B7) is a water-soluble vitamin that uses different pathways for absorption and processing. They do not interfere with each.
अधिक पठन और संदर्भ
- ATP binding cassette subfamily C member 9; MedlinePlus, National Library of Medicine.
- Bienengraeber M, Olson TM, Selivanov VA, Kathmann EC, O'Cochlain F, Gao F, Karger AB, Ballew JD, Hodgson DM, Zingman LV, Pang YP, Alekseev AE, Terzic A. ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet. 2004 Apr;36(4):382-7. doi: 10.1038/ng1329. Epub 2004 Mar 21.
- Bryan J, Munoz A, Zhang X, Dufer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L. ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18. doi: 10.1007/s00424-006-0116-z. Epub 2006 Aug 8.
- Harakalova M, van Harssel JJ, Terhal PA, van Lieshout S, Duran K, Renkens I, Amor DJ, Wilson LC, Kirk EP, Turner CL, Shears D, Garcia-Minaur S, Lees MM, Ross A, Venselaar H, Vriend G, Takanari H, Rook MB, van der Heyden MA, Asselbergs FW, Breur HM, Swinkels ME, Scurr IJ, Smithson SF, Knoers NV, van der Smagt JJ, Nijman IJ, Kloosterman WP, van Haelst MM, van Haaften G, Cuppen E. Dominant missense mutations in ABCC9 cause Cantu syndrome. Nat Genet. 2012 May 18;44(7):793-6. doi: 10.1038/ng.2324.
- Solbach TF, Konig J, Fromm MF, Zolk O. ATP-binding cassette transporters in the heart. Trends Cardiovasc Med. 2006 Jan;16(1):7-15. doi: 10.1016/j.tcm.2005.10.001.
- van Bon BW, Gilissen C, Grange DK, Hennekam RC, Kayserili H, Engels H, Reutter H, Ostergaard JR, Morava E, Tsiakas K, Isidor B, Le Merrer M, Eser M, Wieskamp N, de Vries P, Steehouwer M, Veltman JA, Robertson SP, Brunner HG, de Vries BB, Hoischen A. Cantu syndrome is caused by mutations in ABCC9. Am J Hum Genet. 2012 Jun 8;90(6):1094-101. doi: 10.1016/j.ajhg.2012.04.014. Epub 2012 May 17.
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