calcium voltage-gated channel subunit alpha1 S
अंतिम अद्यतन 18 Aug 2020
मरीज की संपादकीय दिशानिर्देशों
- डाउनलोडडाउनलोड
- साझा करें
- Language
- चर्चा
- ऑडियो संस्करण
- Google पर पसंदीदा स्रोतों में जोड़ें
यह CACNA1S gene provides instructions for making the main piece (subunit) of a structure called a calcium channel. Channels containing the CACNA1S protein are found in muscles used for movement (skeletal muscles). These skeletal muscle calcium channels play a key role in a process called excitation-contraction coupling, by which electrical signals (excitation) trigger muscle tensing (contraction).
Normal function
यह CACNA1S gene provides instructions for making the main piece (subunit) of a structure called a calcium channel. Channels containing the CACNA1S protein are found in muscles used for movement (skeletal muscles). These skeletal muscle calcium channels play a key role in a process called excitation-contraction coupling, by which electrical signals (excitation) trigger muscle tensing (contraction).
Calcium channels made with the CACNA1S subunit are located in the outer membrane of muscle cells, so they can transmit electrical signals from the cell surface to inside the cell. The channels interact with another type of calcium channel called ryanodine receptor 1 (RYR1) channels (produced from the RYR1 gene). RYR1 channels are located in the membrane of a structure inside the cell that stores calcium ions. Signals transmitted by CACNA1S-containing channels turn on (activate) RYR1 channels, which then release calcium ions inside the cells. The resulting increase in calcium ion concentration within muscle cells stimulates muscles to contract, allowing the body to move.
Conditions referring to this gene or chromosome
Other names
CAC1S_HUMAN
CACH1
CACN1
CACNL1A3
calcium channel, voltage-dependent, L type, alpha 1S subunit
Cav1.1
CCHL1A3
DHPR
dihydropyridine receptor
dihydropyridine-sensitive L-type calcium channel alpha-1 subunit
HOKPP
HypoKPP
hypoPP
MHS5
Voltage-dependent L-type calcium channel subunit alpha-1S
voltage-gated calcium channel subunit alpha Cav1.1
Related patient information and medicines
Patient information leaflet
हृदय वाल्व रोग
The leaflet called Anatomy of the heart includes details about the function of. What is heart valve disease. If rheumatic fever is the cause then symptoms often start between the ages of 20 and 50 years, about 10-20 years after having had an episode of rheumatic fever as a child. Other causes of heart valve disease Other causes of heart valve.
Patient information leaflet
क्या मैं लेवोथायरोक्सिन और फेलोडिपाइन को एक साथ ले सकता हूँ?
Taking levothy... If your thyroid levels are not well-controlled, it can change how your body processes the blood pressure medication. Why this happens Levothyroxine is a thyroid hormone, and felodipine है a calcium channel blocker used for high blood pressure. Thyroid hormones affect your metabolism. If you are hyperthyroid (too much hormone) or.
Patient information leaflet
गुर्दे का कैंसर
The cancer grows and forms into a tumour within the kidney. As the tumour grows: The affected kidney tends to become larger. In time the tumour may grow through the wall of the kidney and invade nearby tissues and organs, such as the muscles around the spine, the liver, the nearby large blood vessels, etc. Some cells may break off into the lymph.
Patient information leaflet
क्या मैं कोलेकैल्सीफेरोल और प्रेगाबालिन को एक साथ ले सकता हूँ?
It is generally considered safe to take these t... Why this happens Colecalciferol (Vitamin D3) and pregabalin are processed by the body through different pathways. Colecalciferol is a fat-soluble vitamin involved in कैल्शियम regulation, while pregabalin works on specific calcium channels in the nervous system to treat pain or anxiety. They do not.
Patient information leaflet
क्या मैं एम्लोडिपिन और मेटफॉर्मिन को एक साथ ले सकता हूँ?
Amlodipine may slightly reduce t... This means your blood sugar levels might be a little higher than usual when taking both medicines together. Why this happens एम्लोडिपाइन belongs to a class of drugs called calcium channel blockers. These can sometimes interfere with how the body releases insulin and how it processes sugar, which can slightly.
Patient information leaflet
क्या मैं लेरकेनिडिपाइन और लेवोथायरोक्सिन को एक साथ ले सकता हूँ?
However, if your thyroid levels are not well-controlled, it can affect how your blood pressure medication works. Why this happens Lercanidipine है a calcium channel blocker used for high blood pressure, और levothyroxine is a hormone replacement for an underactive thyroid. They do not interfere with each other's absorption or metabolism. However,.
अधिक पठन और संदर्भ
- calcium voltage-gated channel subunit alpha1 S; MedlinePlus, National Library of Medicine.
- Fouad G, Dalakas M, Servidei S, Mendell JR, Van den Bergh P, Angelini C, Alderson K, Griggs RC, Tawil R, Gregg R, Hogan K, Powers PA, Weinberg N, Malonee W, Ptacek LJ. Genotype-phenotype correlations of DHP receptor alpha 1-subunit gene mutations causing hypokalemic periodic paralysis. Neuromuscul Disord. 1997 Jan;7(1):33-8. doi: 10.1016/s0960-8966(96)00401-4.
- Lehmann-Horn F, Jurkat-Rott K, Rudel R. Periodic paralysis: understanding channelopathies. Curr Neurol Neurosci Rep. 2002 Jan;2(1):61-9. doi: 10.1007/s11910-002-0055-9.
- Miller TM, Dias da Silva MR, Miller HA, Kwiecinski H, Mendell JR, Tawil R, McManis P, Griggs RC, Angelini C, Servidei S, Petajan J, Dalakas MC, Ranum LP, Fu YH, Ptacek LJ. Correlating phenotype and genotype in the periodic paralyses. Neurology. 2004 Nov 9;63(9):1647-55. doi: 10.1212/01.wnl.0000143383.91137.00.
- Monnier N, Procaccio V, Stieglitz P, Lunardi J. Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle. Am J Hum Genet. 1997 Jun;60(6):1316-25. doi: 10.1086/515454.
- Riazi S, Biesecker LG, Rosenberg H, Dirksen RT. Nonsyndromic Malignant Hyperthermia Susceptibility. 2003 Dec 19 [updated 2025 Aug 7]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1146/
- Stewart SL, Hogan K, Rosenberg H, Fletcher JE. Identification of the Arg1086His mutation in the alpha subunit of the voltage-dependent calcium channel (CACNA1S) in a North American family with malignant hyperthermia. Clin Genet. 2001 Mar;59(3):178-84. doi: 10.1034/j.1399-0004.2001.590306.x.
- Venance SL, Cannon SC, Fialho D, Fontaine B, Hanna MG, Ptacek LJ, Tristani-Firouzi M, Tawil R, Griggs RC; CINCH investigators. The primary periodic paralyses: diagnosis, pathogenesis and treatment. Brain. 2006 Jan;129(Pt 1):8-17. doi: 10.1093/brain/awh639. Epub 2005 Sep 29.
- Wang Q, Liu M, Xu C, Tang Z, Liao Y, Du R, Li W, Wu X, Wang X, Liu P, Zhang X, Zhu J, Ren X, Ke T, Wang Q, Yang J. Novel CACNA1S mutation causes autosomal dominant hypokalemic periodic paralysis in a Chinese family. J Mol Med (Berl). 2005 Mar;83(3):203-8. doi: 10.1007/s00109-005-0638-4. Epub 2005 Feb 22.
- Weber F, Lehmann-Horn F. Hypokalemic Periodic Paralysis. 2002 Apr 30 [updated 2018 Jul 26]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1338/
- Yamakage M, Namiki A. Calcium channels--basic aspects of their structure, function and gene encoding; anesthetic action on the channels--a review. Can J Anaesth. 2002 Feb;49(2):151-64. doi: 10.1007/BF03020488.
बातचीत में शामिल हों
हमारे में दूसरों के साथ अपने विचार या अनुभव साझा करें रोगी समुदायों.
पूछें, साझा करें, जुड़ें।.
चर्चाओं को ब्राउज़ करें, प्रश्न पूछें, और सैकड़ों स्वास्थ्य विषयों पर अनुभव साझा करें।.
पेशेंट न्यूज़लेटर के लिए साइन अप करें
आपकी साप्ताहिक खुराक स्पष्ट, विश्वसनीय स्वास्थ्य सलाह की - जो आपको सूचित, आत्मविश्वासी और नियंत्रण में महसूस करने में मदद करने के लिए लिखी गई है।.
सदस्यता लेने पर आप हमारी स्वीकार करते हैं गोपनीयता नीति. आप किसी भी समय सदस्यता समाप्त कर सकते हैं। हम कभी भी आपका डेटा नहीं बेचते।.