intraflagellar transport 140
अंतिम अद्यतन 18 Aug 2020
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यह IFT140 gene provides instructions for making a protein that is involved in the formation and maintenance of cilia, which are microscopic, finger-like projections that stick out from the surface of cells and participate in signaling pathways that transmit information within and between cells. Cilia are important for the structure and function of many types of cells, including cells in the kidneys, liver, and brain. Light-sensing cells (photoreceptors) in the retina also contain cilia, which are essential for normal vision. Cilia also play a role in the development of the bones, although the mechanism is not well understood.
Normal function
यह IFT140 gene provides instructions for making a protein that is involved in the formation and maintenance of cilia, which are microscopic, finger-like projections that stick out from the surface of cells and participate in signaling pathways that transmit information within and between cells. Cilia are important for the structure and function of many types of cells, including cells in the kidneys, liver, and brain. Light-sensing cells (photoreceptors) in the retina also contain cilia, which are essential for normal vision. Cilia also play a role in the development of the bones, although the mechanism is not well understood.
The movement of substances within cilia and similar structures called flagella is known as intraflagellar transport. This process is essential for the assembly and maintenance of these cell structures. During intraflagellar transport, cells use molecules called IFT particles to carry materials to and from the tips of cilia. IFT particles are made of proteins produced from related genes that belong to the IFT gene family. Each IFT particle is made up of two groups of IFT proteins: complex A, which includes at least 6 proteins, and complex B, which includes at least 15 proteins. The protein produced from the IFT140 gene forms part of IFT complex A (IFT-A).
Conditions referring to this gene or chromosome
Other names
c305C8.4
c380F5.1
gs114
IF140_HUMAN
intraflagellar transport 140 homolog (Chlamydomonas)
intraflagellar transport protein 140 homolog
KIAA0590
MZSDS
WD and tetratricopeptide repeats protein 2
WDTC2
Related patient information and medicines
Patient information leaflet
क्या मैं मिराबेग्रोन और रिवारोक्साबन को एक साथ ले सकता हूँ?
Taking these two medicines together... Why this happens Mirabegron and rivaroxaban are processed by different pathways in the body. Mirabegron is primarily broken down by enzymes called CYP3A4 and CYP2D6, while rivaroxaban is processed by CYP3A4 and a transport protein called P-gp. While they share the CYP3A4 pathway, studies show that mirabegron.
Patient information leaflet
क्या मैं अलोग्लिप्टिन और एपिक्साबैन को एक साथ ले सकता हूँ?
There are no known significant interactions between alogliptin and apixaban. It is generally ... Why this happens Alogliptin (a diabetes medication) and apixaban (a blood thinner) are processed by different pathways in the body. Alogliptin is primarily excreted unchanged by the kidneys, while apixaban is processed by specific liver enzymes.
Patient information leaflet
क्या मैं एटोरवास्टेटिन और रिवारोक्साबैन को एक साथ ले सकता हूँ?
Taking atorvastatin and rivaroxaban together may slightly increase the levels of rivaroxaban in your blood. Why this happens Both medications are processed by the same enzyme system in the liver (CYP3A4) and a transport protein (P-gp). Beca... Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions.
Patient information leaflet
क्या मैं नॉरट्रिप्टिलाइन और रोसुवास्टेटिन को एक साथ ले सकता हूँ?
These two medicines work in different ways and are processed by different pathways in the body. Why this happens Nortriptyline is a tricyclic antidepressant primarily broken down by liver enzymes known as CYP2D6. रोसुवास्टेटिन is a स्टेटिन used for cholesterol that is mostly processed by different enzymes (CYP2C9) and transport proteins. Because.
Patient information leaflet
क्या मैं एपिक्साबैन और एम्पाग्लिफ्लोज़िन को एक साथ ले सकता हूँ?
Why this happens Apixaban (a blood thinner) and empagliflozin (a diabetes medication) are processed by different pathways in the body. Apixaban is mainly broken down by specific liver enzymes (CYP3A4) and a transport protein (P-gp), while empagliflozin is processed through a different liver pathway (glucuronidation) and removed by the kidneys..
Patient information leaflet
क्या मैं एटोरवास्टेटिन और लिक्सियाना को एक साथ ले सकता हूँ?
While Lixiana is a blood thinner that directly prevents clots, atorvastatin can occasionally cause side effects that might complicate your treatment. Why this happens Atorvastatin is processed by a specific liver enzyme (CYP3A4), while Lixiana is mainly cleared by the kidneys and a transport protein (P-gp). Because they use different pathways,.
अधिक पठन और संदर्भ
- intraflagellar transport 140; MedlinePlus, National Library of Medicine.
- Behal RH, Miller MS, Qin H, Lucker BF, Jones A, Cole DG. Subunit interactions and organization of the Chlamydomonas reinhardtii intraflagellar transport complex A proteins. J Biol Chem. 2012 Apr 6;287(15):11689-703. doi: 10.1074/jbc.M111.287102. Epub 2011 Dec 14.
- Jonassen JA, SanAgustin J, Baker SP, Pazour GJ. Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation. J Am Soc Nephrol. 2012 Apr;23(4):641-51. doi: 10.1681/ASN.2011080829. Epub 2012 Jan 26.
- Perrault I, Saunier S, Hanein S, Filhol E, Bizet AA, Collins F, Salih MA, Gerber S, Delphin N, Bigot K, Orssaud C, Silva E, Baudouin V, Oud MM, Shannon N, Le Merrer M, Roche O, Pietrement C, Goumid J, Baumann C, Bole-Feysot C, Nitschke P, Zahrate M, Beales P, Arts HH, Munnich A, Kaplan J, Antignac C, Cormier-Daire V, Rozet JM. Mainzer-Saldino syndrome is a ciliopathy caused by IFT140 mutations. Am J Hum Genet. 2012 May 4;90(5):864-70. doi: 10.1016/j.ajhg.2012.03.006. Epub 2012 Apr 12.
- Schmidts M, Frank V, Eisenberger T, Al Turki S, Bizet AA, Antony D, Rix S, Decker C, Bachmann N, Bald M, Vinke T, Toenshoff B, Di Donato N, Neuhann T, Hartley JL, Maher ER, Bogdanovic R, Peco-Antic A, Mache C, Hurles ME, Joksic I, Guc-Scekic M, Dobricic J, Brankovic-Magic M, Bolz HJ, Pazour GJ, Beales PL, Scambler PJ, Saunier S, Mitchison HM, Bergmann C. Combined NGS approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney Disease. Hum Mutat. 2013 May;34(5):714-24. doi: 10.1002/humu.22294.
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