lysophosphatidic acid receptor 6
अंतिम अद्यतन 12 अप्रैल 2023
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यह LPAR6 gene provides instructions for making a protein called lysophosphatidic acid receptor 6 (LPA6). This protein functions as a receptor. Receptor proteins have particular sites into which certain other proteins, called ligands, fit like keys into locks. A specific fat called lysophosphatidic acid (LPA) is the ligand for the LPA6 protein. LPA can attach to many receptors, but LPA6 is the only LPA receptor found in hair follicles. Hair follicles are specialized structures in the skin where hair growth occurs. As the cells in the hair follicle divide, the hair strand (shaft) is pushed upward and extends beyond the skin, causing the hair to grow. The LPA6 protein is also found in the outermost layer of skin (the epidermis). Attachment of LPA to LPA6 helps regulate the growth and division (proliferation) and maturation (differentiation) of cells in the hair follicle.
Normal function
यह LPAR6 gene provides instructions for making a protein called lysophosphatidic acid receptor 6 (LPA6). This protein functions as a receptor. Receptor proteins have particular sites into which certain other proteins, called ligands, fit like keys into locks. A specific fat called lysophosphatidic acid (LPA) is the ligand for the LPA6 protein. LPA can attach to many receptors, but LPA6 is the only LPA receptor found in hair follicles. Hair follicles are specialized structures in the skin where hair growth occurs. As the cells in the hair follicle divide, the hair strand (shaft) is pushed upward and extends beyond the skin, causing the hair to grow. The LPA6 protein is also found in the outermost layer of skin (the epidermis). Attachment of LPA to LPA6 helps regulate the growth and division (proliferation) and maturation (differentiation) of cells in the hair follicle.
Conditions referring to this gene or chromosome
Other names
G-protein coupled purinergic receptor P2Y5
LPA receptor 6
LPA-6
LPAR6_HUMAN
oleoyl-L-alpha-lysophosphatidic acid receptor
P2RY5
P2Y purinoceptor 5
P2Y5
purinergic receptor 5
purinergic receptor P2Y G protein-coupled protein 5
purinergic receptor P2Y, G-protein coupled, 5
RB intron encoded G-protein coupled receptor
Related patient information and medicines
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एसिड रिफ्लक्स और इसोफैगाइटिस
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Patient information leaflet
क्या मैं एलेंड्रोनिक एसिड और लैंसोप्राज़ोल को एक साथ ले सकता हूँ?
Taking lansoprazole may make alendronic acid less effective at strengthening आपका bones. हमारा Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements हैं सुरक्षित को take together. ...er This information is for general educational purposes only and should not be relied upon as a substitute.
Patient information leaflet
क्या मैं ब्लैक कोहोश और फोलिक एसिड को एक साथ ले सकता हूँ?
Black cohosh है primarily broken down by liver enzymes (specifically यह CYP450 system), while folic acid is a water-soluble B vitamin that follows a separate metabolic route. They do not interfere with each other's a... Using other medicines Taking multiple medicines. Our दवाओं की परस्पर क्रिया जाँचकर्ता helps you check whether your prescriptions,.
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क्या मैं फोलिक एसिड और ओएस्ट्रोजेल पंप-पैक को एक साथ ले सकता हूँ?
It is safe to use these two treatments together. Why this happens फोलिक एसिड है a B vitamin used by the body to make healthy cells, while Oestrogel है a hormone replacement therapy (HRT) that provides oestradiol through the skin. These substances are processed by the body through different pathways and do not interfere with how the other is.
Patient information leaflet
क्या मैं फोलिक एसिड और सेंट जॉन वॉर्ट को एक साथ ले सकता हूँ?
There is no known significant interaction between folic acid and St John's wort. It is generally considered safe to take these two together. Why this happens Folic acid is a water-soluble B vitamin, while St John's wort is an herbal remedy primarily used for low mood. They are processed by different pathways in the body and do not interfere with.
अधिक पठन और संदर्भ
- lysophosphatidic acid receptor 6; MedlinePlus, National Library of Medicine.
- Azeem Z, Jelani M, Naz G, Tariq M, Wasif N, Kamran-Ul-Hassan Naqvi S, Ayub M, Yasinzai M, Amin-Ud-Din M, Wali A, Ali G, Chishti MS, Ahmad W. Novel mutations in G protein-coupled receptor gene (P2RY5) in families with autosomal recessive hypotrichosis (LAH3). Hum Genet. 2008 Jun;123(5):515-9. doi: 10.1007/s00439-008-0507-7. Epub 2008 May 7.
- Khan S, Habib R, Mir H, Umm-e-Kalsoom, Naz G, Ayub M, Shafique S, Yamin T, Ali N, Basit S, Wasif N, Kamran-Ul-Hassan Naqvi S, Ali G, Wali A, Ansar M, Ahmad W. Mutations in the LPAR6 and LIPH genes underlie autosomal recessive hypotrichosis/woolly hair in 17 consanguineous families from Pakistan. Clin Exp Dermatol. 2011 Aug;36(6):652-4. doi: 10.1111/j.1365-2230.2011.04014.x. Epub 2011 Mar 21.
- Kurban M, Wajid M, Shimomura Y, Christiano AM. Mutations in LPAR6/P2RY5 and LIPH are associated with woolly hair and/or hypotrichosis. J Eur Acad Dermatol Venereol. 2013 May;27(5):545-9. doi: 10.1111/j.1468-3083.2012.04472.x. Epub 2012 Mar 5.
- Pasternack SM, von Kugelgen I, Al Aboud K, Lee YA, Ruschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nurnberg P, Nothen MM, Betz RC. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet. 2008 Mar;40(3):329-34. doi: 10.1038/ng.84. Epub 2008 Feb 24.
- Shimomura Y, Wajid M, Ishii Y, Shapiro L, Petukhova L, Gordon D, Christiano AM. Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nat Genet. 2008 Mar;40(3):335-9. doi: 10.1038/ng.100. Epub 2008 Feb 24.
- Tariq M, Ayub M, Jelani M, Basit S, Naz G, Wasif N, Raza SI, Naveed AK, ullah Khan S, Azeem Z, Yasinzai M, Wali A, Ali G, Chishti MS, Ahmad W. Mutations in the P2RY5 gene underlie autosomal recessive hypotrichosis in 13 Pakistani families. Br J Dermatol. 2009 May;160(5):1006-10. doi: 10.1111/j.1365-2133.2009.09046.x. Epub 2009 Mar 9.
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