Can I take Codeine and Morphine together?

Why this happens

Both codeine and morphine work by attaching to the same receptors in the brain and spinal cord to block pain. Additionally, the body naturally converts a portion of codeine into morphine after you swallow it. Taking both means you are essentially taking a double dose of morphine, which can overwhelm the central nervous system.

What you should do

You should not take codeine and morphine together unless specifically instructed and closely monitored by a specialist. If you have been prescribed both, speak to your doctor or pharmacist immediately to clarify the dosing schedule. Seek emergency medical help if you experience extreme drowsiness, confusion, shallow breathing, or difficulty waking up.

Important precautions

Breathing problems (e.g. COPD, severe asthma)

These medicines can dangerously slow your breathing. Do not take them if you have severe lung disease or are having an asthma attack.

Alcohol consumption

Drinking alcohol while taking these medicines significantly increases the risk of life-threatening breathing difficulties and extreme sleepiness.

Addiction and Dependency

Codeine contains an opioid which can cause addiction if used for more than 3 days. Long-term use can lead to withdrawal symptoms when you stop.

Breastfeeding

Do not take codeine while breastfeeding. It passes into breast milk and can cause life-threatening breathing problems or extreme sleepiness in your baby.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. Combining alcohol with strong painkillers like codeine or morphine significantly increases the risk of dangerous side effects, such as extreme sleepiness, breathing difficulties, and a potentially fatal overdose.

Grapefruit juice

Grapefruit juice can interfere with how your body processes codeine. This may make the medicine less effective at relieving pain or, in some cases, increase the risk of side effects. It is best to avoid drinking large amounts of grapefruit juice while taking codeine.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.