Can I take Ibuprofen and Naproxen together?

Do not take ibuprofen and naproxen at the same time. If one is not managing your pain, speak to a pharmacist or doctor about adding a different type of painkiller, such as paracetamol, which works differently and is generally safe to take alongside one NSAID.

Why this happens

Both ibuprofen and naproxen belong to the same family of medicines called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). They work by blocking the same enzymes in the body.

Taking both is like taking a double dose of the same type of medicine; it doesn't provide better pain relief but it does double the strain on your stomach lining and kidneys.

How to know if you're having a drug interaction

You may be experiencing an interaction between ibuprofen and naproxen if:

• You took ibuprofen and naproxen together or close in time.

• You have black, tarry, or bloody poo (stools).

• You have stomach pain, heartburn, or feeling sick (nausea).

• You feel dizzy or very tired.

• You notice swelling, shortness of breath, or chest pain,

• You pee less than usual or have swollen ankles/legs.

What you should do

If you have any of the above symptoms, you should:

• Stop taking ibuprofen and naproxen (don’t mix them).

• Use paracetamol instead for pain, unless a doctor says otherwise.

• Get urgent help for chest pain, breathing problems, severe stomach pain, or vomiting blood/black stools.

• Contact a GP or pharmacist if symptoms are mild but don’t go away.

• Drink water and avoid alcohol while you recover.

Important precautions

Asthma

Do not take these medicines if you have asthma, as they can trigger a severe or life-threatening asthma attack (bronchospasm).

Stomach ulcers or bleeding

Avoid these medicines if you have ever had a stomach ulcer or gastrointestinal bleeding, as they significantly increase the risk of serious internal bleeding and perforation.

Pregnancy (third trimester)

Do not take these medicines if you are more than 28 weeks pregnant, as they can cause serious heart and kidney problems in the unborn baby and complications during birth.

Food and drink warnings

Alcohol

Drinking alcohol while taking NSAIDs like ibuprofen or naproxen can increase the risk of stomach irritation, stomach ulcers, and gastrointestinal bleeding. It is best to limit alcohol intake or avoid it entirely if you have a history of stomach issues.

Food (General)

While not an interaction that changes how the drug works, you should ideally take these medicines with or just after food or a snack. This helps to protect your stomach lining and reduces the risk of indigestion or stomach pain.

Using other medicines?

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.