Can I take Pregabalin and Paracetamol together?

Why this happens

Pregabalin and paracetamol work in different ways and are processed by different organs in the body. Pregabalin is mainly cleared by the kidneys, while paracetamol is processed by the liver. They do not interfere with how the other is absorbed or removed from the body.

What you should do

You can take these medicines together as prescribed by your doctor or as directed on the packaging. Always stick to the recommended doses for both. If you feel unusually drowsy, speak to your pharmacist or doctor, as pregabalin itself can sometimes cause tiredness.

Important precautions

Mental health disorders

Pregabalin can cause suicidal thoughts or an urge to self-harm. You must seek medical help immediately if your mood changes or you have thoughts of hurting yourself.

Severe respiratory depression

Pregabalin can cause serious breathing problems, especially if you already have lung disease or if you take it with other sedating medicines like opioids. Seek emergency help if you experience slow, shallow, or difficult breathing.

History of substance misuse or addiction

Pregabalin carries a high risk of dependence and addiction. You must take it exactly as prescribed and be aware that it can be misused.

Pregnancy

Pregabalin should not be used during pregnancy as it may increase the risk of major birth defects. Effective contraception must be used during treatment.

Concurrent use of other medicines

Many over-the-counter remedies (such as cold and flu powders) contain paracetamol. Taking more than one product containing paracetamol can lead to a fatal overdose.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking paracetamol. Combining alcohol and paracetamol increases the risk of serious liver damage.

Drinking alcohol while taking pregabalin can significantly increase feelings of sleepiness, dizziness, and confusion. It may also impair your coordination and increase the risk of breathing problems. It is best to avoid or strictly limit alcohol until you know how the medicine affects you.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.