cholinergic receptor nicotinic beta 2 subunit
अंतिम अद्यतन 8 Aug 2025
मरीज की संपादकीय दिशानिर्देशों
- डाउनलोडडाउनलोड
- साझा करें
- Language
- चर्चा
- ऑडियो संस्करण
- Google पर पसंदीदा स्रोतों में जोड़ें
The CHRNB2 gene provides instructions for making one part (subunit) of a larger protein complex called a nicotinic acetylcholine receptor (nAChR). Each nAChR complex is made up of a combination of five subunits, usually two alpha (α) and three beta (β) subunits. Many different combinations are possible, and the characteristics of each nAChR complex depend on its specific subunits. In the brain, the complex most commonly consists of two α4 subunits and three β2 subunits. The CHRNB2 gene is responsible for producing the β2 subunit.
Normal function
The CHRNB2 gene provides instructions for making one part (subunit) of a larger protein complex called a nicotinic acetylcholine receptor (nAChR). Each nAChR complex is made up of a combination of five subunits, usually two alpha (α) and three beta (β) subunits. Many different combinations are possible, and the characteristics of each nAChR complex depend on its specific subunits. In the brain, the complex most commonly consists of two α4 subunits and three β2 subunits. The CHRNB2 gene is responsible for producing the β2 subunit.
In the brain, nAChR proteins are widely distributed and play an important role in chemical signaling between nerve cells (neurons). The nAChR acts as a channel, allowing charged atoms (ions), including calcium, sodium, and potassium, to cross the cell membrane. These channels open when they attach to a chemical messenger (neurotransmitter) called acetylcholine. The channels also open in response to nicotine, the addictive substance in tobacco.
Communication between neurons depends on neurotransmitters, which are released from one neuron and taken up by neighboring neurons. The release and uptake of these chemicals are tightly regulated to ensure that signals are passed efficiently and accurately between neurons. Researchers believe that nAChR channels play an important role in controlling the normal release and uptake of neurotransmitters.
A wide range of brain functions depend on nAChR channels, including sleep and arousal, fatigue, anxiety, attention, pain perception, and memory. The channels are also active before birth, which suggests that they are involved in early brain development.
Conditions referring to this gene or chromosome
Other names
acetylcholine receptor, neuronal nicotinic, beta-2 subunit
cholinergic receptor, nicotinic beta 2
cholinergic receptor, nicotinic, beta 2 (neuronal)
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
EFNL3
nAChRB2
Related patient information and medicines
Patient information leaflet
मौखिक ब्रोन्कोडायलेटर
Oral bronchodilators are medicines that are sometimes used to treat breathing problems in people with asthma and other lung-related problems such as chronic obstructive pulmonary disease (COPD). These are beta 2 agonists (salbutamol, bambuterol and terbutaline) and methylxanthines (theophylline and aminophylline). Beta 2 agonists Work by.
Patient information leaflet
टाइप 2 मधुमेह
Treatment aim 2 - to... Even mildly raised blood pressure should be treated if you have type 2 diabetes. As well as expert help and advice, medication or निकोटीन replacement therapy (nicotine gum, etc) may help you to stop. This will help to lower the risk of developing some complications such as heart disease , peripheral arterial disease and.
Patient information leaflet
क्या मैं पायरिडोस्टिग्माइन और रामिप्रिल को एक साथ ले सकता हूँ?
Use effective contraception while taking this medicine. Cholinergic Crisis (Overdose) - pyridostigmine If you experience severe muscle weakness, abdominal cramps, or difficulty breathing, seek urgent medical help. These can be signs of an overdose, which can look very similar to the condition being treated. Our दवाओं की परस्पर क्रिया जाँचकर्ता helps.
Patient information leaflet
थैलेसीमिया
For the more severe forms of thalassaemia, modern treatment gives a good outlook, but lifelong monitoring and treatment are needed. Haemoglobin is made out of different parts. The main parts are called alpha chains and beta chains which are put together to make the haemoglobin molecule. In thalassaemia, part of the haemoglobin is faulty - usually.
Patient information leaflet
क्या मैं रॉयल सन और शिटाके को एक साथ ले सकता हूँ?
Both Royal Sun (Agaricus blazei) and Shiitake (Lentinula edodes) mushrooms contain high levels का beta-glucans, which are substances that stimulate the immune system. Taking them together may cause your immune system to become ... Our दवाओं की परस्पर क्रिया जाँचकर्ता helps you check whether your prescriptions, over-the-counter medicines, and.
Patient information leaflet
क्या मैं ओमेप्राज़ोल और पायरिडोस्टिग्माइन को एक साथ ले सकता हूँ?
Important precautions Asthma or COPD Pyridostigmine can cause narrowing of the airways and increase mucus production, which may severely worsen breathing problems or trigger an asthma attack. Cholinergic Crisis (Overdose) - pyridostigmine If you experience severe muscle weakness, abdominal cramps, or difficulty breathing, seek urgent medical help..
अधिक पठन और संदर्भ
- cholinergic receptor nicotinic beta 2 subunit; MedlinePlus, National Library of Medicine.
- Arneric SP, Holladay M, Williams M. Neuronal nicotinic receptors: a perspective on two decades of drug discovery research. Biochem Pharmacol. 2007 Oct 15;74(8):1092-101. doi: 10.1016/j.bcp.2007.06.033. Epub 2007 Jun 26.
- Bertrand D, Elmslie F, Hughes E, Trounce J, Sander T, Bertrand S, Steinlein OK. The CHRNB2 mutation I312M is associated with epilepsy and distinct memory deficits. Neurobiol Dis. 2005 Dec;20(3):799-804. doi: 10.1016/j.nbd.2005.05.013. Epub 2005 Jun 17.
- Bertrand D, Picard F, Le Hellard S, Weiland S, Favre I, Phillips H, Bertrand S, Berkovic SF, Malafosse A, Mulley J. How mutations in the nAChRs can cause ADNFLE epilepsy. Epilepsia. 2002;43 Suppl 5:112-22. doi: 10.1046/j.1528-1157.43.s.5.16.x.
- Bertrand S, Weiland S, Berkovic SF, Steinlein OK, Bertrand D. Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy. Br J Pharmacol. 1998 Oct;125(4):751-60. doi: 10.1038/sj.bjp.0702154.
- Cho YW, Yi SD, Lim JG, Kim DK, Motamedi GK. Autosomal dominant nocturnal frontal lobe epilepsy and mild memory impairment associated with CHRNB2 mutation I312M in the neuronal nicotinic acetylcholine receptor. Epilepsy Behav. 2008 Aug;13(2):361-5. doi: 10.1016/j.yebeh.2008.04.017. Epub 2008 Jun 4.
- De Fusco M, Becchetti A, Patrignani A, Annesi G, Gambardella A, Quattrone A, Ballabio A, Wanke E, Casari G. The nicotinic receptor beta 2 subunit is mutant in nocturnal frontal lobe epilepsy. Nat Genet. 2000 Nov;26(3):275-6. doi: 10.1038/81566.
- di Corcia G, Blasetti A, De Simone M, Verrotti A, Chiarelli F. Recent advances on autosomal dominant nocturnal frontal lobe epilepsy: "understanding the nicotinic acetylcholine receptor (nAChR)". Eur J Paediatr Neurol. 2005;9(2):59-66. doi: 10.1016/j.ejpn.2004.12.006.
- Hoda JC, Gu W, Friedli M, Phillips HA, Bertrand S, Antonarakis SE, Goudie D, Roberts R, Scheffer IE, Marini C, Patel J, Berkovic SF, Mulley JC, Steinlein OK, Bertrand D. Human nocturnal frontal lobe epilepsy: pharmocogenomic profiles of pathogenic nicotinic acetylcholine receptor beta-subunit mutations outside the ion channel pore. Mol Pharmacol. 2008 Aug;74(2):379-91. doi: 10.1124/mol.107.044545. Epub 2008 May 2.
- Kurahashi H, Hirose S. Autosomal Dominant Sleep-Related Hypermotor (Hyperkinetic) Epilepsy. 2002 May 16 [updated 2023 Mar 23]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1169/
- Marini C, Guerrini R. The role of the nicotinic acetylcholine receptors in sleep-related epilepsy. Biochem Pharmacol. 2007 Oct 15;74(8):1308-14. doi: 10.1016/j.bcp.2007.06.030. Epub 2007 Jun 23.
- Phillips HA, Favre I, Kirkpatrick M, Zuberi SM, Goudie D, Heron SE, Scheffer IE, Sutherland GR, Berkovic SF, Bertrand D, Mulley JC. CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy. Am J Hum Genet. 2001 Jan;68(1):225-31. doi: 10.1086/316946. Epub 2000 Dec 5.
बातचीत में शामिल हों
हमारे में दूसरों के साथ अपने विचार या अनुभव साझा करें रोगी समुदायों.
पूछें, साझा करें, जुड़ें।.
चर्चाओं को ब्राउज़ करें, प्रश्न पूछें, और सैकड़ों स्वास्थ्य विषयों पर अनुभव साझा करें।.
पेशेंट न्यूज़लेटर के लिए साइन अप करें
आपकी साप्ताहिक खुराक स्पष्ट, विश्वसनीय स्वास्थ्य सलाह की - जो आपको सूचित, आत्मविश्वासी और नियंत्रण में महसूस करने में मदद करने के लिए लिखी गई है।.
सदस्यता लेने पर आप हमारी स्वीकार करते हैं गोपनीयता नीति. आप किसी भी समय सदस्यता समाप्त कर सकते हैं। हम कभी भी आपका डेटा नहीं बेचते।.