histone deacetylase 8
अंतिम अद्यतन 11 Apr 2023
मरीज की संपादकीय दिशानिर्देशों
- डाउनलोडडाउनलोड
- साझा करें
- Language
- चर्चा
- ऑडियो संस्करण
- Google पर पसंदीदा स्रोतों में जोड़ें
यह HDAC8 gene provides instructions for making an enzyme called histone deacetylase 8. This enzyme is involved in regulating the structure and organisation of chromosomes during cell division.
Normal function
यह HDAC8 gene provides instructions for making an enzyme called histone deacetylase 8. This enzyme is involved in regulating the structure and organisation of chromosomes during cell division.
Before cells divide, they must copy all of their chromosomes. The copied DNA from each chromosome is arranged into two identical structures called sister chromatids. Sister chromatids are attached to one another during the early stages of cell division by a group of proteins called the cohesin complex. Later in cell division, the cohesin complex must be removed so the sister chromatids can separate, allowing one from each pair to move into each newly forming cell. Histone deacetylase 8 carries out a chemical reaction that helps remove the cohesin complex so it can be recycled for future cell divisions.
Researchers believe that histone deacetylase 8, as a regulator of the cohesin complex, also plays important roles in stabilizing cells' genetic information, repairing damaged DNA, and controlling the activity of certain genes that are essential for normal development.
Conditions referring to this gene or chromosome
Other names
CDA07
CDLS5
HD8
HDACL1
histone deacetylase-like 1
MRXS6
RPD3
WTS
Related patient information and medicines
Patient information leaflet
पेफिगस वल्गेरिस
पेफिगस वल्गेरिस is a very serious skin disease that causes blisters. It is rare. Pemphigus vulgaris is more serious than most other blistering skin conditions. These different conditions vary grea... Pemphigus vulgaris is the most common form of pemphigus and one of the most serious blistering skin conditions. This leaflet is only about.
Patient information leaflet
बच्चों में एक्जिमा
These are prescribed by your doctor or dermatology specialist if needed Antihistami... If itching causes sleep disturbance then a sedating antihistamine may be best. Otherwise a non-sedating antihistamine may be preferable because sedating एंटीहिस्टामिन कारण बन सकता है नींद आना into the following day, even when given just before bedtime. Your doctor.
Patient information leaflet
गुदा विदर
You may also bleed when you pass stools - the blood is typically bright red, in the pan या on the toilet paper. Bleeding from the back passage should always be checked by a doctor. For some people, the fissure heals within 1-2 weeks or so but it can take much longer. Those that heals within six weeks are known as acute anal fissures whereas a.
Patient information leaflet
लार ग्रंथि विकार
This is due to infection spreading from the mouth and is more common in people who are otherwise unwell with other problems. Tuberculosis occasionally affects the salivary glands. लार ग्रंथि के पत्थर यह chemicals in spit (saliva) can sometimes crystallise into a stone that can then block the salivary ducts. Some people form one or more small.
%20and%20Matcha%20together%3F/og.png)
Patient information leaflet
क्या मैं Certican (Everolimus) और Matcha को एक साथ ले सकता हूँ?
This could lead to an increased risk of ... Why this happens Certican is broken down in the body by a specific enzyme (CYP3A4) and a transport protein (P-glycoprotein). Matcha, which is a concentrated form of green tea, contains high levels of catechins. These natural compounds can interfere with these enzymes and proteins, slowing down how.
Patient information leaflet
म्यूकोसाइटिस
Mucositis affects the lining of your mouth or gut (bowel) और is often caused by chemotherapy or radiotherapy. Mucositis is often very painful and needs strong painkillers to help control the pain. It often interferes with eating and drinking and has a very negative effect on your quality of life. However, it can be prevented, can be treated and.
अधिक पठन और संदर्भ
- histone deacetylase 8; MedlinePlus, National Library of Medicine.
- Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, Saitoh K, Komata M, Katou Y, Clark D, Cole KE, De Baere E, Decroos C, Di Donato N, Ernst S, Francey LJ, Gyftodimou Y, Hirashima K, Hullings M, Ishikawa Y, Jaulin C, Kaur M, Kiyono T, Lombardi PM, Magnaghi-Jaulin L, Mortier GR, Nozaki N, Petersen MB, Seimiya H, Siu VM, Suzuki Y, Takagaki K, Wilde JJ, Willems PJ, Prigent C, Gillessen-Kaesbach G, Christianson DW, Kaiser FJ, Jackson LG, Hirota T, Krantz ID, Shirahige K. HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature. 2012 Sep 13;489(7415):313-7. doi: 10.1038/nature11316.
- Decroos C, Bowman CM, Moser JA, Christianson KE, Deardorff MA, Christianson DW. Compromised structure and function of HDAC8 mutants identified in Cornelia de Lange Syndrome spectrum disorders. ACS Chem Biol. 2014 Sep 19;9(9):2157-64. doi: 10.1021/cb5003762. Epub 2014 Jul 30.
- Harakalova M, van den Boogaard MJ, Sinke R, van Lieshout S, van Tuil MC, Duran K, Renkens I, Terhal PA, de Kovel C, Nijman IJ, van Haelst M, Knoers NV, van Haaften G, Kloosterman W, Hennekam RC, Cuppen E, Ploos van Amstel HK. X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face. J Med Genet. 2012 Aug;49(8):539-43. doi: 10.1136/jmedgenet-2012-100921.
- Kaiser FJ, Ansari M, Braunholz D, Concepcion Gil-Rodriguez M, Decroos C, Wilde JJ, Fincher CT, Kaur M, Bando M, Amor DJ, Atwal PS, Bahlo M, Bowman CM, Bradley JJ, Brunner HG, Clark D, Del Campo M, Di Donato N, Diakumis P, Dubbs H, Dyment DA, Eckhold J, Ernst S, Ferreira JC, Francey LJ, Gehlken U, Guillen-Navarro E, Gyftodimou Y, Hall BD, Hennekam R, Hudgins L, Hullings M, Hunter JM, Yntema H, Innes AM, Kline AD, Krumina Z, Lee H, Leppig K, Lynch SA, Mallozzi MB, Mannini L, McKee S, Mehta SG, Micule I; Care4Rare Canada Consortium; Mohammed S, Moran E, Mortier GR, Moser JA, Noon SE, Nozaki N, Nunes L, Pappas JG, Penney LS, Perez-Aytes A, Petersen MB, Puisac B, Revencu N, Roeder E, Saitta S, Scheuerle AE, Schindeler KL, Siu VM, Stark Z, Strom SP, Thiese H, Vater I, Willems P, Williamson K, Wilson LC; University of Washington Center for Mendelian Genomics; Hakonarson H, Quintero-Rivera F, Wierzba J, Musio A, Gillessen-Kaesbach G, Ramos FJ, Jackson LG, Shirahige K, Pie J, Christianson DW, Krantz ID, Fitzpatrick DR, Deardorff MA. Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance. Hum Mol Genet. 2014 Jun 1;23(11):2888-900. doi: 10.1093/hmg/ddu002. Epub 2014 Jan 8.
- Mordaunt DA, McLauchlan A. HDAC8-deficiency causes an X-linked dominant disorder with a wide range of severity. Clin Genet. 2015 Jul;88(1):98. doi: 10.1111/cge.12588. Epub 2015 Apr 10. No abstract available.
बातचीत में शामिल हों
हमारे में दूसरों के साथ अपने विचार या अनुभव साझा करें रोगी समुदायों.
पूछें, साझा करें, जुड़ें।.
चर्चाओं को ब्राउज़ करें, प्रश्न पूछें, और सैकड़ों स्वास्थ्य विषयों पर अनुभव साझा करें।.
पेशेंट न्यूज़लेटर के लिए साइन अप करें
आपकी साप्ताहिक खुराक स्पष्ट, विश्वसनीय स्वास्थ्य सलाह की - जो आपको सूचित, आत्मविश्वासी और नियंत्रण में महसूस करने में मदद करने के लिए लिखी गई है।.
सदस्यता लेने पर आप हमारी स्वीकार करते हैं गोपनीयता नीति. आप किसी भी समय सदस्यता समाप्त कर सकते हैं। हम कभी भी आपका डेटा नहीं बेचते।.