myelin protein zero
अंतिम अद्यतन 18 Aug 2020
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यह MPZ gene provides instructions for making a protein called myelin protein zero. It is the most abundant protein in myelin, a protective substance that covers nerves and promotes the efficient transmission of nerve impulses. Myelin protein zero is produced by specialized cells called Schwann cells, which wrap around and insulate peripheral nerves. Peripheral nerves connect the brain and spinal cord to muscles and to sensory cells that detect sensations such as touch, pain, heat, and sound. Myelin protein zero is required for the proper formation and maintenance of myelin. This protein is an adhesion molecule, which means it acts like molecular glue. It plays a role in tightly packing the myelin around nerve cells (myelin compaction).
Normal function
यह MPZ gene provides instructions for making a protein called myelin protein zero. It is the most abundant protein in myelin, a protective substance that covers nerves and promotes the efficient transmission of nerve impulses. Myelin protein zero is produced by specialized cells called Schwann cells, which wrap around and insulate peripheral nerves. Peripheral nerves connect the brain and spinal cord to muscles and to sensory cells that detect sensations such as touch, pain, heat, and sound. Myelin protein zero is required for the proper formation and maintenance of myelin. This protein is an adhesion molecule, which means it acts like molecular glue. It plays a role in tightly packing the myelin around nerve cells (myelin compaction).
Conditions referring to this gene or chromosome
Other names
CMT1B
CMT2I
CMT2J
HMSN1B
MPP
myelin glycoprotein P-zero
myelin peripheral protein
myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)
MYP0_HUMAN
P0 Glycoprotein
P0 Protein
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अधिक पठन और संदर्भ
- myelin protein zero; MedlinePlus, National Library of Medicine.
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- Krokengen OC, Touma C, Mularski A, Sutinen A, Dunkel R, Ytterdal M, Raasakka A, Mertens HDT, Simonsen AC, Kursula P. The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes. Biochim Biophys Acta Biomembr. 2024 Oct;1866(7):184368. doi: 10.1016/j.bbamem.2024.184368. Epub 2024 Jul 4.
- Mandich P, Fossa P, Capponi S, Geroldi A, Acquaviva M, Gulli R, Ciotti P, Manganelli F, Grandis M, Bellone E. Clinical features and molecular modelling of novel MPZ mutations in demyelinating and axonal neuropathies. Eur J Hum Genet. 2009 Sep;17(9):1129-34. doi: 10.1038/ejhg.2009.37. Epub 2009 Mar 18.
- Shy ME. Peripheral neuropathies caused by mutations in the myelin protein zero. J Neurol Sci. 2006 Mar 15;242(1-2):55-66. doi: 10.1016/j.jns.2005.11.015. Epub 2006 Jan 18.
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