succinate dehydrogenase complex subunit C
अंतिम अद्यतन 13 Jul 2021
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यह SDHC gene provides instructions for making one of four subunits of the succinate dehydrogenase (SDH) enzyme. The SDH enzyme plays a critical role in mitochondria, which are structures inside cells that convert the energy from food into a form that cells can use. The SDHC protein helps anchor the SDH enzyme in the mitochondrial membrane.
Normal function
यह SDHC gene provides instructions for making one of four subunits of the succinate dehydrogenase (SDH) enzyme. The SDH enzyme plays a critical role in mitochondria, which are structures inside cells that convert the energy from food into a form that cells can use. The SDHC protein helps anchor the SDH enzyme in the mitochondrial membrane.
Within mitochondria, the SDH enzyme links two important cellular pathways in energy conversion: the citric acid cycle (or Krebs cycle) and oxidative phosphorylation. As part of the citric acid cycle, the SDH enzyme converts a compound called succinate to another compound called fumarate. Negatively charged particles called electrons are released during this reaction. The electrons are transferred through the SDH subunits, including the SDHC protein, to the oxidative phosphorylation pathway. In oxidative phosphorylation, the electrons help create an electrical charge that provides energy for the production of adenosine triphosphate (ATP), the cell's main energy source.
Succinate, the compound on which the SDH enzyme acts, is an oxygen sensor in the cell and can help turn on specific pathways that stimulate cells to grow in a low-oxygen environment (hypoxia). In particular, succinate stabilizes a protein called hypoxia-inducible factor (HIF) by preventing a reaction that would allow HIF to be broken down. HIF controls several important genes involved in cell division and the formation of new blood vessels in a hypoxic environment.
यह SDHC gene is a tumour suppressor, which means it prevents cells from growing and dividing in an uncontrolled way.
Conditions referring to this gene or chromosome
Other names
C560_HUMAN
CYB560
CYBL
cytochrome B large subunit of complex II
integral membrane protein CII-3
integral membrane protein CII-3b
PGL3
QPs-1
QPS1
SDH3
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
succinate dehydrogenase cytochrome b560 subunit, mitochondrial
succinate-ubiquinone oxidoreducatase cytochrome B large subunit
succinate-ubiquinone oxidoreductase cytochrome B large subunit
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अधिक पठन और संदर्भ
- succinate dehydrogenase complex subunit C; MedlinePlus, National Library of Medicine.
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- Stratakis CA, Carney JA. The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications. J Intern Med. 2009 Jul;266(1):43-52. doi: 10.1111/j.1365-2796.2009.02110.x.
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