WRN RecQ like helicase
अंतिम अद्यतन 27 Jun 2022
मरीज की संपादकीय दिशानिर्देशों
- डाउनलोडडाउनलोड
- साझा करें
- Language
- चर्चा
- ऑडियो संस्करण
- Google पर पसंदीदा स्रोतों में जोड़ें
यह WRN gene provides instructions for producing the Werner protein, which plays a critical role in repairing damaged DNA. The Werner protein functions as a type of enzyme called a helicase. Helicase enzymes generally unwind and separate double-stranded DNA. The Werner protein also functions as an enzyme called an exonuclease. Exonucleases trim the broken ends of damaged DNA by removing DNA building blocks (nucleotides). Research suggests that the Werner protein first unwinds the DNA and then removes abnormal DNA structures that have been accidentally generated.
Normal function
यह WRN gene provides instructions for producing the Werner protein, which plays a critical role in repairing damaged DNA. The Werner protein functions as a type of enzyme called a helicase. Helicase enzymes generally unwind and separate double-stranded DNA. The Werner protein also functions as an enzyme called an exonuclease. Exonucleases trim the broken ends of damaged DNA by removing DNA building blocks (nucleotides). Research suggests that the Werner protein first unwinds the DNA and then removes abnormal DNA structures that have been accidentally generated.
Overall, the Werner protein helps maintain the structure and integrity of a person's DNA. This protein plays an important role in copying (replicating) DNA before cell division and transferring the information in genes to the cell machinery that makes proteins (transcription). Additionally, recent studies suggest that the Werner protein may be particularly important for maintaining DNA at the ends of chromosomes (telomeres).
Conditions referring to this gene or chromosome
Other names
RECQ3
RECQL2
RECQL3
Werner syndrome
Werner Syndrome helicase
Werner syndrome protein
Werner syndrome, RecQ helicase-like
WRN_HUMAN
Related patient information and medicines
Patient information leaflet
क्या मैं वेनलाफैक्सिन और वेलब्यूट्रिन को एक साथ ले सकता हूँ?
Using other medicines Taking multiple medicines. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them. Disclaimer This information is for general educational.
Patient information leaflet
क्या मैं Lansoprazole और Rivaroxaban को एक साथ ले सकता हूँ?
...nce of a significant interaction between lansoprazole and rivaroxabanDisclaimer This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications..
Patient information leaflet
गैंग्लियन
ए ganglion cyst is a harmless fluid-filled lump which can occur near joints or tendons. They are most commonly found on the wrists or hands. They are harmless but can cause discomfort, pain and weakness. Sometime... What is a ganglion cyst. A ganglion cyst is a small सूजन that contains a thick jelly-like material. It looks and feels like a.
Patient information leaflet
आंखों की चोटों से निपटना
This leaflet is created from first aid advice provided by St John Ambulance, the nation's leading first aid charity. This advice is no substitute for first aid training - find a training course near you. Eye injuries vary from something very minor, such as getting shampoo in your eye, to something quite serious, such as a cut, which could cause.
Patient information leaflet
क्या मैं लेवोथायरोक्सिन और वेनलाफैक्सिन को एक साथ ले सकता हूँ?
However, if ... Additionally, both medications can occasionally affect your heart rate or rhythm, particularly if your levothyroxine dose is too high. Why this happens Levothyroxine is a thyroid hormone replacement, and venlafaxine is an antidepressant (SNRI). They do not interfere with each other's absorption or metabolism in the liver. However,.
Patient information leaflet
कार्यात्मक न्यूरोलॉजिकल विकार
यह term functional neurological disorder encompasses a wide range of symptoms that are often very debilitating. Doctors tend to categorise these symptoms according to their medical frame of reference, but often fail. Functional neurological disorders have no formal way of being diagnosed by doctors. They can, however, be treated. What are.
अधिक पठन और संदर्भ
- WRN RecQ like helicase; MedlinePlus, National Library of Medicine.
- Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, Fraga MF, Herranz M, Paz MF, Sanchez-Cespedes M, Artiga MJ, Guerrero D, Castells A, von Kobbe C, Bohr VA, Esteller M. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8822-7. doi: 10.1073/pnas.0600645103. Epub 2006 May 24.
- Cheng WH, Muftuoglu M, Bohr VA. Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase. Exp Gerontol. 2007 Sep;42(9):871-8. doi: 10.1016/j.exger.2007.04.011. Epub 2007 May 10.
- Comai L, Li B. The Werner syndrome protein at the crossroads of DNA repair and apoptosis. Mech Ageing Dev. 2004 Aug;125(8):521-8. doi: 10.1016/j.mad.2004.06.004.
- Futami K, Ishikawa Y, Goto M, Furuichi Y, Sugimoto M. Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells. Cancer Sci. 2008 May;99(5):843-8. doi: 10.1111/j.1349-7006.2008.00778.x. Epub 2008 Feb 26.
- Huang S, Lee L, Hanson NB, Lenaerts C, Hoehn H, Poot M, Rubin CD, Chen DF, Yang CC, Juch H, Dorn T, Spiegel R, Oral EA, Abid M, Battisti C, Lucci-Cordisco E, Neri G, Steed EH, Kidd A, Isley W, Showalter D, Vittone JL, Konstantinow A, Ring J, Meyer P, Wenger SL, von Herbay A, Wollina U, Schuelke M, Huizenga CR, Leistritz DF, Martin GM, Mian IS, Oshima J. The spectrum of WRN mutations in Werner syndrome patients. Hum Mutat. 2006 Jun;27(6):558-67. doi: 10.1002/humu.20337.
- Kudlow BA, Kennedy BK, Monnat RJ Jr. Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol. 2007 May;8(5):394-404. doi: 10.1038/nrm2161.
- Lee JW, Harrigan J, Opresko PL, Bohr VA. Pathways and functions of the Werner syndrome protein. Mech Ageing Dev. 2005 Jan;126(1):79-86. doi: 10.1016/j.mad.2004.09.011.
- Monnat RJ Jr, Saintigny Y. Werner syndrome protein--unwinding function to explain disease. Sci Aging Knowledge Environ. 2004 Mar 31;2004(13):re3. doi: 10.1126/sageke.2004.13.re3.
- Opresko PL, Calvo JP, von Kobbe C. Role for the Werner syndrome protein in the promotion of tumor cell growth. Mech Ageing Dev. 2007 Jul-Aug;128(7-8):423-36. doi: 10.1016/j.mad.2007.05.009. Epub 2007 May 31.
- Oshima J, Hisama FM. Werner Syndrome. 2002 Dec 2 [updated 2026 Mar 25]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1514/
- Ozgenc A, Loeb LA. Current advances in unraveling the function of the Werner syndrome protein. Mutat Res. 2005 Sep 4;577(1-2):237-51. doi: 10.1016/j.mrfmmm.2005.03.020.
बातचीत में शामिल हों
हमारे में दूसरों के साथ अपने विचार या अनुभव साझा करें रोगी समुदायों.
पूछें, साझा करें, जुड़ें।.
चर्चाओं को ब्राउज़ करें, प्रश्न पूछें, और सैकड़ों स्वास्थ्य विषयों पर अनुभव साझा करें।.
पेशेंट न्यूज़लेटर के लिए साइन अप करें
आपकी साप्ताहिक खुराक स्पष्ट, विश्वसनीय स्वास्थ्य सलाह की - जो आपको सूचित, आत्मविश्वासी और नियंत्रण में महसूस करने में मदद करने के लिए लिखी गई है।.
सदस्यता लेने पर आप हमारी स्वीकार करते हैं गोपनीयता नीति. आप किसी भी समय सदस्यता समाप्त कर सकते हैं। हम कभी भी आपका डेटा नहीं बेचते।.